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- Title
Axis of ageing: telomeres, p53 and mitochondria.
- Authors
Sahin, Ergün; DePinho, Ronald A.
- Abstract
Progressive DNA damage and mitochondrial decline are both considered to be prime instigators of natural ageing. Traditionally, these two pathways have been viewed largely in isolation. However, recent studies have revealed a molecular circuit that directly links DNA damage to compromised mitochondrial biogenesis and function via p53. This axis of ageing may account for both organ decline and disease development associated with advanced age and could illuminate a path for the development of relevant therapeutics.
- Subjects
DNA; DNA damage; CELL membrane formation; AGING; THERAPEUTICS
- Publication
Nature Reviews Molecular Cell Biology, 2012, Vol 13, Issue 6, p397
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm3352