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- Title
Slow Periodic Spasms and Rapidly Progressive Parkinsonism Due to Cerebral Amyloid Angiopathy.
- Authors
Silva, Daniela Pimenta; Coelho, Pedro; Silva, Cláudia Santos; Campos, Catarina Falcão; Franco, Ana Catarina; Valadas, Anabela; Antunes, Ana Patrícia; Albuquerque, Luísa
- Abstract
9 Yamashita Y, Hatano T, Ogawa T, Daida K, Motoi Y, Hattori N. Steroid-responsive parkinsonism caused by cerebral amyloid angiopathy-related inflammation. Keywords: rapidly progressive parkinsonism; slow periodic waves; cerebral amyloid angiopathy EN rapidly progressive parkinsonism slow periodic waves cerebral amyloid angiopathy S21 S25 5 09/14/22 20220902 NES 220902 Cerebral amyloid angiopathy (CAA) is characterized by progressive deposition of A protein in the walls of small- to medium-sized leptomeningeal and cortical blood vessels.1 Clinical manifestations include symptomatic acute lobar intracerebral hemorrhage, chronic progressive cognitive decline and transient focal neurological episodes, with widespread cortical microbleeds in brain MRI.1 Rarely, it can present as cerebral amyloid angiopathy-related inflammation (CAA-ri) in which there is a perivascular inflammation around amyloid-laden vessels, along with rapid clinical progression and adding cortico-subcortical T2/fluid-attenuated inversion recovery (FLAIR) hyperintensities in brain MRI. (D) 18F-Florbetaben amyloid PET imaging - diffuse amyloid deposition. gl Amyloid CSF biomarkers disclosed decreased A 42 level (231; N>620 ng/L) and A 42/A 40 ratio (0.41; N>0.72).
- Subjects
CEREBRAL amyloid angiopathy; PARKINSONIAN disorders; SPASMS; LYME disease; PROGRESSIVE supranuclear palsy; CEREBRAL palsy
- Publication
Movement Disorders Clinical Practice, 2022, Vol 9, pS21
- ISSN
2330-1619
- Publication type
Article
- DOI
10.1002/mdc3.13539