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- Title
Silk fibroin/polyurethane patch implantation in hyperglycemic rat model.
- Authors
Kitpipatkun, Pitipat; Sutummaporn, Kripitch; Kato, Konosuke; Murakami, Tomoaki; Kobayashi, Kyoko; Nakazawa, Yasumoto; Tanaka, Ryou
- Abstract
Purpose: To understand the complication and histopathological characteristics between the Silk Fibroin/Polyurethanes (SF/PU) and the host response, and to unveil the compatibility of the patch in diabetes individuals. Methods: Rats were divided into DM and control (CT) groups, and the DM group was induced with streptozotocin. All groups underwent the SF/PU patch implantation in the abdominal aorta, and the implanted patches were evaluated at one, two, three, and four weeks after implantation. Results: DM group had more fibrosis formation and a delayed endothelialization compared to the CT group. There was no evidence of chronic inflammation in both DM and CT groups. Conclusions: Fibrosis in hyperglycemic individuals could promote the formation of new vascular structures in the implanted patch such as endothelial and vascular smooth muscle cells. In summary, the SF/PU patch was no serious complications when implanted under hyperglycemia, and the patch was suitable to implant in diabetes mellitus.
- Subjects
ANIMAL disease models; SILK fibroin; POLYURETHANE elastomers; RATS; HYPERGLYCEMIA; VASCULAR smooth muscle; POLYURETHANES; SILKWORMS; ABDOMINAL aorta
- Publication
Journal of Biomaterials Applications, 2021, Vol 36, Issue 4, p701
- ISSN
0885-3282
- Publication type
Article
- DOI
10.1177/0885328221999227