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- Title
COMPUTERIZED MORPHOMETRIC ASSESSMENT OF THE HUMAN RED BLOOD CELLS TREATED WITH CISPLATIN.
- Authors
Bischin, Cristina; Ţălu, Ş.; Silaghi-Dumitrescu, R.; Ţălu, M.; Giovanzana, S.; Alina Lupaşcu, Carmen
- Abstract
The objective of this study is to perform an evaluation of representative size and shape parameters that characterise the human red blood cells either exposed to cisplatin or exposed to control solutions containing no cisplatin. A set of fourteen digital images corresponding for the human red blood cells were evaluated. Image processing and analysis of digital images were performed with ImageJ and MRI Cell Image Analyzer (MRI-CIA) softwares. We found for the human red blood cells either exposed to cisplatin or exposed to control solutions containing no cisplatin, a set of representative size and shape parameters for quantification. The central tendency and dispersion measure of the parameters were expressed by the mean value and standard deviation. The computerized geometric morphometric analysis of the human red blood cells is an efficient noninvasive prediction tool that provides important insights into cell states.
- Subjects
ERYTHROCYTE disorders; CISPLATIN; ALKYLATING agents; MEDICAL imaging systems; DIAGNOSTIC imaging; MORPHOMETRICS; ONTOGENY; PHYSIOLOGY; THERAPEUTICS
- Publication
Annals of the Romanian Society for Cell Biology, 2012, Vol 17, Issue 2, p105
- ISSN
2067-3019
- Publication type
Article