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- Title
In-depth Characterization of Vaccine Breakthrough Infections With SARS-CoV-2 Among Health Care Workers in a Dutch Academic Medical Center.
- Authors
Rümke, Lidewij W; Groenveld, Femke C; Os, Yvonne M G van; Praest, Patrique; Tanja, Anniek A N; Jong, Dorien T C M de; Symons, Jori; Schuurman, Rob; Reinders, Tessa; Hofstra, L Marije; Nierkens, Stefan; Thijsen, Steven F T; Heron, Michiel; Lebbink, Robert-Jan; Beekman, Jeffrey M; Nijhuis, Monique; Wensing, Annemarie M J
- Abstract
Severe acute respiratory syndrome coronavirus 2 infection after coronavirus disease 2019 vaccination raises concerns about the emergence of vaccine escape variants. Here we characterize 14 breakthrough infections among 5860 fully vaccinated Dutch health care workers ≥14 days after the final dose of vaccination with either BNT162b2, mRNA-1273, or Ad26.COV2.S. These breakthrough infections presented with regular B.1.1.7 (Alpha) and B.1.617.2 (Delta) variants and high viral loads, despite normal vaccine-induced B- and T-cell immune responses detected by live virus neutralization assays and ELISpot. High-risk exposure settings, such as in households, indicate a potential risk of viral transmission despite full vaccination.
- Publication
Open Forum Infectious Diseases, 2022, Vol 9, Issue 1, p1
- ISSN
2328-8957
- Publication type
Article
- DOI
10.1093/ofid/ofab553