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- Title
Chronic Stress Induced by Keeping in Conditions of Nesting Material Deficiency in the Early Postnatal Period Affects Behavior and Stress Reactivity in Male Rats.
- Authors
Stepanichev, M. Yu.; Nedogreeva, O. A.; Klimanova, M. A.; Moiseeva, Yu. V.; Onufriev, M. V.; Lazareva, N. A.; Gulyaeva, N. V.
- Abstract
Rodent models of deprivation of parental care are increasingly used to model depression-like disorders induced by early stress. The present study used a model of the consequences of mothers and offspring being kept in conditions of nesting material deficiency (NMD) for a prolonged period in early postnatal ontogeny in rats. The aim of this study was to determine whether the behavior of male rats exposed to stress due to being kept in conditions of NMD in the early postnatal period changes and whether any such changes are associated with impairments to the animals' stress reactivity. Keeping of rats in conditions of NMD from postnatal day 2 to postnatal day 9 did not lead to any significant changes in measures of behavior pointing to anxiety and depressivity recorded in standard tests (open field test, elevated plus maze, sucrose solution preference) either in adolescence or adulthood. NMD in the early postnatal period produced an increase in social attachment (extent of socially oriented behavior manifest as the desire to spend more time in the presence of an unfamiliar individual in a novel context) in one-month-old but not adult animals. Keeping in conditions of NMD improved spatial learning but had no effect on long-term memory in adult rats on assessment of the ability of adults to learn to solve a spatial task in the Barnes maze. Changes in stress reactivity in animals (dynamics of release of corticosterone into the blood) were most marked in adult rats. Thus, NMD in the early postnatal period did not induce anxiety or depression-like behavior in male rats at ages 1 or 6 months but had transient effects on social attachment in young animals and altered stress reactivity on short-term exposure to a moderate stressor (restraint).
- Subjects
PUERPERIUM; PSYCHOLOGICAL stress; IMMOBILIZATION stress; RATS; EFFECT of stress on animals; MAZE tests
- Publication
Neuroscience & Behavioral Physiology, 2022, Vol 52, Issue 1, p97
- ISSN
0097-0549
- Publication type
Article
- DOI
10.1007/s11055-022-01212-8