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- Title
Background and distribution of lobar microbleeds in cognitive dysfunction.
- Authors
Matsuyama, Hirofumi; Ii, Yuichiro; Maeda, Masayuki; Umino, Maki; Ueda, Yukito; Tabei, Ken‐ichi; Kida, Hirotaka; Satoh, Masayuki; Shindo, Akihiro; Taniguchi, Akira; Takahashi, Ryosuke; Tomimoto, Hidekazu
- Abstract
Objectives Cerebral microbleeds ( CMBs) are often observed in memory clinic patients. It has been generally accepted that deep CMBs (D- CMBs) result from hypertensive vasculopathy ( HV), whereas strictly lobar CMBs ( SL- CMBs) result from cerebral amyloid angiopathy ( CAA) which frequently coexists with Alzheimer's disease ( AD). Mixed CMBs (M- CMBs) have been partially attributed to HV and also partially attributed to CAA. The aim of this study was to elucidate the differences between SL- CMBs and M- CMBs in terms of clinical features and regional distribution. Materials We examined 176 sequential patients in our memory clinic for clinical features and CMB location using susceptibility-weighted images obtained on a 3T- MRI. The number of lobar CMBs in SL- CMBs and M- CMBs was counted in each cerebral lobe and their regional density was adjusted according to the volume of each lobe. Results Of the total 176 patients, 111 patients (63.1%) had CMBs. Within the patients who had CMBs, M- CMBs were found in 54 patients (48.6%), followed by SL- CMBs in 35 (31.5%) and D- CMBs in 19 (17.1%). The SL- CMB group showed a significantly higher prevalence of family history of dementia, whereas the M- CMB group showed an increasing trend toward hypertension and smoking. The prevalence of AD was significantly higher in the SL- CMBs group, whereas the prevalence of AD with cerebrovascular disease was higher in the M- CMBs group. The regional density of lobar CMBs was significantly higher in the occipital lobe in the M- CMB group, whereas the SL- CMB group showed higher regional density between regions an increasing tendency in the parietal and occipital lobe. Conclusion The between-group differences in clinical features and regional distribution indicate there to be an etiological relationship of SL- CMBs to AD and CAA, and M- CMBs to both HV and CAA.
- Subjects
CEREBRAL amyloid angiopathy; ALZHEIMER'S disease diagnosis; DISEASE prevalence; GENEALOGY; COGNITION; MAGNETIC resonance imaging of the brain; DIAGNOSIS
- Publication
Brain & Behavior, 2017, Vol 7, Issue 11, pn/a
- ISSN
2162-3279
- Publication type
Article
- DOI
10.1002/brb3.856