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- Title
A P300-based cognitive assessment battery.
- Authors
Kirschner, Aaron; Cruse, Damian; Chennu, Srivas; Owen, Adrian M.; Hampshire, Adam
- Abstract
Background It is well established that some patients who are diagnosed as being in a vegetative state or a minimally conscious state show reliable signs of volition that may only be detected by measuring neural responses. A pertinent question is whether these patients are capable of higher cognitive processes. Methods Here, we develop a series of EEG paradigms that probe several core aspects of cognition at the bedside without the need for motor responses and explore the sensitivity of this approach in a group of healthy controls. Results Using analysis of ERPs alone, this method can determine with high reliability whether individual participants are able to attend a stimulus stream, maintain items in working memory, or solve complex grammatical reasoning problems. Conclusion We suggest that this approach could form the basis of a brain-based battery for assessing higher cognition in patients with severe motor impairments or disorders of consciousness.
- Subjects
COGNITIVE testing; PERSISTENT vegetative state; CONSCIOUSNESS; SHORT-term memory; ELECTROENCEPHALOGRAPHY
- Publication
Brain & Behavior, 2015, Vol 5, Issue 6, pn/a
- ISSN
2162-3279
- Publication type
Article
- DOI
10.1002/brb3.336