We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
5-Fluorouracil and its active metabolite FdUMP cause DNA damage in human SW620 colon adenocarcinoma cell line.
- Authors
Matuo, Renata; Sousa, Fabricio Garmus; Escargueil, Alexandre E.; Grivicich, Ivana; Garcia-Santos, Daniel; Bogo, José Artur; Saffi, Jenifer; Larsen, Annette K.; Henriques, João Antonio Pêgas
- Abstract
The article focuses on a research which investigated the cytotoxic effects of 5-fluorouracil (5-FU) and its active metabolite fluorodeoxyuridine monophosphate (FdUMP) to the DNA in human SW620 colon adenocarcinoma cell line. It analyzed the ability of %-FU and FdUMP to influence the cell cycle progression in human colon SW620 adenocarcinoma cells in regards to genotoxic and clastogenic activities. It is revealed that 5-FU induces Single-sideband modulation (SSB), double-strand breaks (DSBs) and apoptosis which create DNA damage in human SW620 colon adenocarcinoma than FdUMP.
- Subjects
FLUOROURACIL; DNA damage; GENETIC toxicology; TOXICOLOGICAL interactions; CELL lines; APOPTOSIS; ANTINEOPLASTIC agents; MICROBIAL cell cycle; ADENOCARCINOMA; METABOLITES; RESEARCH
- Publication
Journal of Applied Toxicology, 2009, Vol 29, Issue 4, p308
- ISSN
0260-437X
- Publication type
Article
- DOI
10.1002/jat.1411