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A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite.
Published in:
eLife, 2023, p. 1, doi. 10.7554/eLife.82207
By:
- Ramaprasad, Abhinay;
- Burda, Paul-Christian;
- Calvani, Enrica;
- Sait, Aaron J.;
- Palma-Duran, Susana Alejandra;
- Withers-Martinez, Chrislaine;
- Hackett, Fiona;
- Macrae, James;
- Collinson, Lucy;
- Gilberger, Tim Wolf;
- Blackman, Michael J.
Publication type:
Article
Targeted Deletion of a Plasmodium Site-2 Protease Impairs Life Cycle Progression in the Mammalian Host.
Published in:
PLoS ONE, 2017, v. 12, n. 1, p. 1, doi. 10.1371/journal.pone.0170260
By:
- Koussis, Konstantinos;
- Goulielmaki, Evi;
- Chalari, Anna;
- Withers-Martinez, Chrislaine;
- Siden-Kiamos, Inga;
- Matuschewski, Kai;
- Loukeris, Thanasis G.
Publication type:
Article
Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite.
Published in:
Journal of Cell Biology, 2006, v. 174, n. 7, p. 1023, doi. 10.1083/jcb.200604136
By:
- O'Donnell, Rebecca A.;
- Hackett, Fiona;
- Howell, Steven A.;
- Treeck, Moritz;
- Struck, Nicole;
- Krnajski, Zita;
- Withers-Martinez, Chrislaine;
- Gilberger, Tim W.;
- Blackman, Michael J.
Publication type:
Article
A multifunctional serine protease primes the malaria parasite for red blood cell invasion.
Published in:
EMBO Journal, 2009, v. 28, n. 6, p. 725, doi. 10.1038/emboj.2009.22
By:
- Koussis, Konstantinos;
- Withers-Martinez, Chrislaine;
- Yeoh, Sharon;
- Child, Matthew;
- Hackett, Fiona;
- Knuepfer, Ellen;
- Juliano, Luiz;
- Woehlbier, Ute;
- Bujard, Hermann;
- Blackman, Michael J.
Publication type:
Article
Characterization of P. falciparum dipeptidyl aminopeptidase 3 specificity identifies differences in amino acid preferences between peptide‐based substrates and covalent inhibitors.
Published in:
FEBS Journal, 2019, v. 286, n. 20, p. 3998, doi. 10.1111/febs.14953
By:
- Vries, Laura E.;
- Sanchez, Mateo I.;
- Groborz, Katarzyna;
- Kuppens, Laurie;
- Poreba, Marcin;
- Lehmann, Christine;
- Nevins, Neysa;
- Withers‐Martinez, Chrislaine;
- Hirst, David J.;
- Yuan, Fang;
- Arastu‐Kapur, Shirin;
- Horn, Martin;
- Mares, Michael;
- Bogyo, Matthew;
- Drag, Marcin;
- Deu, Edgar
Publication type:
Article
Malaria Parasite cGMP-dependent Protein Kinase Regulates Blood Stage Merozoite Secretory Organelle Discharge and Egress
Published in:
PLoS Pathogens, 2013, v. 9, n. 5, p. 1, doi. 10.1371/journal.ppat.1003344
By:
- Collins, Christine R.;
- Hackett, Fiona;
- Strath, Malcolm;
- Penzo, Maria;
- Withers-Martinez, Chrislaine;
- Baker, David A.;
- Blackman, Michael J.
Publication type:
Article
Juxtamembrane Shedding of Plasmodium falciparum AMA1 Is Sequence Independent and Essential, and Helps Evade Invasion-Inhibitory Antibodies.
Published in:
PLoS Pathogens, 2011, v. 7, n. 12, p. 1, doi. 10.1371/journal.ppat.1002448
By:
- Olivieri, Anna;
- Collins, Christine R.;
- Hackett, Fiona;
- Withers-Martinez, Chrislaine;
- Marshall, Joshua;
- Flynn, Helen R.;
- Skehel, J. Mark;
- Blackman, Michael J.
Publication type:
Article
An Inhibitory Antibody Blocks Interactions between Components of the Malarial Invasion Machinery.
Published in:
PLoS Pathogens, 2009, v. 5, n. 1, p. 1, doi. 10.1371/journal.ppat.1000273
By:
- Collins, Christine R.;
- Withers-Martinez, Chrislaine;
- Fiona Hackett;
- Blackman, Michael J.
Publication type:
Article
Molecular Identification of a Malaria Merozoite Surface Sheddase.
Published in:
PLoS Pathogens, 2005, v. 1, n. 3, p. 241, doi. 10.1371/journal.ppat.0010029
By:
- Harris, Philippa K.;
- Yeoh, Sharon;
- Dluzewski, Anton R.;
- O'Donnell, Rebecca A.;
- Withers-Martinez, Chrislaine;
- Hackett, Fiona;
- Bannister, Lawrence H.;
- Mitchell, Graham H.;
- Blackman, Michael J.
Publication type:
Article
P lasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle.
Published in:
Molecular Microbiology, 2015, v. 96, n. 2, p. 368, doi. 10.1111/mmi.12941
By:
- Stallmach, Robert;
- Kavishwar, Manoli;
- Withers‐Martinez, Chrislaine;
- Hackett, Fiona;
- Collins, Christine R.;
- Howell, Steven A.;
- Yeoh, Sharon;
- Knuepfer, Ellen;
- Atid, Avshalom J.;
- Holder, Anthony A.;
- Blackman, Michael J.
Publication type:
Article
Distinct mechanisms govern proteolytic shedding of a key invasion protein in apicomplexan pathogens.
Published in:
Molecular Microbiology, 2005, v. 57, n. 5, p. 1342, doi. 10.1111/j.1365-2958.2005.04772.x
By:
- Howell, Steven A.;
- Hackett, Fiona;
- Jongco, Artemio M.;
- Withers-Martinez, Chrislaine;
- Kim, Kami;
- Carruthers, Vern B.;
- Blackman, Michael J.
Publication type:
Article
Subtilisin-like proteases of the malaria parasite.
Published in:
Molecular Microbiology, 2004, v. 53, n. 1, p. 55, doi. 10.1111/j.1365-2958.2004.04144.x
By:
- Withers-martinez, Chrislaine;
- Jean, Létitia;
- Blackman, Michael J.
Publication type:
Article
Activation loop phosphorylation and cGMP saturation of PKG regulate egress of malaria parasites.
Published in:
PLoS Pathogens, 2024, v. 20, n. 6, p. 1, doi. 10.1371/journal.ppat.1012360
By:
- Koussis, Konstantinos;
- Haase, Silvia;
- Withers-Martinez, Chrislaine;
- Flynn, Helen R.;
- Kunzelmann, Simone;
- Christodoulou, Evangelos;
- Ibrahim, Fairouz;
- Skehel, Mark;
- Baker, David A.;
- Blackman, Michael J.
Publication type:
Article
Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery.
Published in:
PLoS Biology, 2019, v. 17, n. 5, p. 1, doi. 10.1371/journal.pbio.3000264
By:
- Patel, Avnish;
- Perrin, Abigail J.;
- Flynn, Helen R.;
- Bisson, Claudine;
- Withers-Martinez, Chrislaine;
- Treeck, Moritz;
- Flueck, Christian;
- Nicastro, Giuseppe;
- Martin, Stephen R.;
- Ramos, Andres;
- Gilberger, Tim W.;
- Snijders, Ambrosius P.;
- Blackman, Michael J.;
- Baker, David A.
Publication type:
Article
Molecular Determinants for Subcellular Trafficking of the Malarial Sheddase PfSUB2.
Published in:
Traffic, 2013, v. 14, n. 10, p. 1053, doi. 10.1111/tra.12092
By:
- Child, Matthew A.;
- Harris, Philippa K.;
- Collins, Christine R.;
- Withers‐Martinez, Chrislaine;
- Yeoh, Sharon;
- Blackman, Michael J.
Publication type:
Article
Corrigendum: The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin.
Published in:
Nature Communications, 2014, v. 5, n. 5, p. 4031, doi. 10.1038/ncomms5031
By:
- Withers-Martinez, Chrislaine;
- Strath, Malcolm;
- Hackett, Fiona;
- Haire, Lesley F.;
- Howell, Steven A.;
- Walker, Philip A.;
- Christodoulou, Evangelos;
- Dodson, Guy G.;
- Blackman, Michael J.
Publication type:
Article
The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin.
Published in:
Nature Communications, 2014, v. 5, n. 5, p. 3726, doi. 10.1038/ncomms4726
By:
- Withers-Martinez, Chrislaine;
- Strath, Malcolm;
- Hackett, Fiona;
- Haire, Lesley F.;
- Howell, Steven A.;
- Walker, Philip A.;
- Evangelos, Christodoulou;
- Dodson, Guy G.;
- Blackman, Michael J.
Publication type:
Article
Essentiality of Plasmodium falciparum plasmepsin V.
Published in:
PLoS ONE, 2018, v. 13, n. 12, p. 1, doi. 10.1371/journal.pone.0207621
By:
- Boonyalai, Nonlawat;
- Collins, Christine R.;
- Hackett, Fiona;
- Withers-Martinez, Chrislaine;
- Blackman, Michael J.
Publication type:
Article
Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor.
Published in:
EMBO Journal, 2021, v. 40, n. 11, p. 1, doi. 10.15252/embj.2020107226
By:
- Tan, Michele S Y;
- Koussis, Konstantinos;
- Withers‐Martinez, Chrislaine;
- Howell, Steven A;
- Thomas, James A;
- Hackett, Fiona;
- Knuepfer, Ellen;
- Shen, Min;
- Hall, Matthew D;
- Snijders, Ambrosius P;
- Blackman, Michael J
Publication type:
Article

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