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- Title
Relationship of left ventricular mass to coronary atherosclerosis and myocardial ischaemia: the CORE320 multicenter study.
- Authors
Satoru Kishi; Magalhaes, Tiago A.; George, Richard T.; Dewey, Marc; Laham, Roger J.; Hiroyuki Niinuma; Aronson Friedman, Lisa; Cox, Christopher; Tanami, Yutaka; Schuijf, Joanne D.; Vavere, Andrea L.; Kitagawa, Kakuya; Chen, Marcus Y.; Nomura, Cesar H.; Brinker, Jeffrey A.; Rybicki, Frank J.; Di Carli, Marcelo F.; Arbab-Zadeh, Armin; Lima, Joao A. C.
- Abstract
Aims The aim of this study was to investigate the association of left ventricular mass (LVM) with coronary atherosclerosis and myocardial infarction (MI). Methods and results Patients (n = 338) underwent 320 x 0.5 mm detector row coronary computed tomography (CT) angiography, invasive coronary angiography (ICA), and single-photon emission CT (SPECT) myocardial perfusion imaging. Quantitative coronary atheroma volume was obtained from the CT images for the entire coronary tree (19-segment model) with an arterial contour detection algorithm. Normalized total atheroma volume (NormTAV) was analysed to reflect quantitative total atheroma volume. LVM was measured on myocardial CT images and indexed to height to the power of 2.7 (LVMi). Patients with obstructive coronary artery disease (CAD) were defined as those with ≥50% diameter stenosis by quantitative ICA. Abnormal perfusion defect was defined as ≥1 abnormal myocardial segment by SPECT. The association of LVMi with coronary atherosclerosis and myocardial perfusion defect on SPECT at the patient level was determined with uni- and multivariable linear and logistic regression analyses. Obstructive CAD was present in 60.0% of enrolled patients. LVMi was independently associated with abnormal summed rest score [SRS; odds ratio (OR), 1.07; 95% confidence interval (CI), 1.03-1.09] and summed stress score (OR, 1.04; 95% CI, 1.01-1.07). An increase in LVMi was also independently associated with that in NormTAV (coefficient, 10.44; 95% CI, 1.50-19.39) and SRS ≥1 (OR, 1.05; 95% CI, 1.01-1.10), even after adjusting for cardiovascular risk factors in patients without previous MI. Conclusions LVM was independently associated with the presence of coronary artery atherosclerosis and MI.
- Subjects
DIAGNOSIS; BLOOD vessels; COMPUTED tomography; CONFIDENCE intervals; CORONARY disease; MULTIVARIATE analysis; MYOCARDIAL infarction; REGRESSION analysis; LOGISTIC regression analysis; CARDIAC-gated SPECT; ODDS ratio; LEFT ventricular hypertrophy
- Publication
European Heart Journal - Cardiovascular Imaging, 2015, Vol 16, Issue 2, p166
- ISSN
2047-2404
- Publication type
Article
- DOI
10.1093/ehjci/jeu217