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- Title
Hyperpolarized NMR Spectroscopy: d‐DNP, PHIP, and SABRE Techniques.
- Authors
Kovtunov, Kirill V.; Pokochueva, Ekaterina V.; Salnikov, Oleg G.; Cousin, Samuel F.; Kurzbach, Dennis; Vuichoud, Basile; Jannin, Sami; Chekmenev, Eduard Y.; Goodson, Boyd M.; Barskiy, Danila A.; Koptyug, Igor V.
- Abstract
Abstract: The intensity of NMR signals can be enhanced by several orders of magnitude by using various techniques for the hyperpolarization of different molecules. Such approaches can overcome the main sensitivity challenges facing modern NMR/magnetic resonance imaging (MRI) techniques, whilst hyperpolarized fluids can also be used in a variety of applications in material science and biomedicine. This Focus Review considers the fundamentals of the preparation of hyperpolarized liquids and gases by using dissolution dynamic nuclear polarization (d‐DNP) and parahydrogen‐based techniques, such as signal amplification by reversible exchange (SABRE) and parahydrogen‐induced polarization (PHIP), in both heterogeneous and homogeneous processes. The various new aspects in the formation and utilization of hyperpolarized fluids, along with the possibility of observing NMR signal enhancement, are described.
- Subjects
NUCLEAR magnetic resonance spectroscopy; MEDICINE; POLARIZATION (Nuclear physics); PARAHYDROGEN; MATERIALS science
- Publication
Chemistry - An Asian Journal, 2018, Vol 13, Issue 15, p1857
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/asia.201800551