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- Title
Fermented mixed grain ameliorates chronic stress-induced depression-like behavior and memory deficit.
- Authors
Song, Jae Gwang; Lee, Bomi; Kim, Do Eon; Seo, Bong Kyeong; Oh, Nam Su; Kim, Sae Hun; Kim, Hyung Wook
- Abstract
Fermented mixed grain (FG) has beneficial anti-cancer, antioxidant, and anti-inflammatory effects. In this study, we investigated the effects of FG on gut inflammation, brain dysfunction, and anxiety/depression-like behavior induced by unpredictable chronic mild stress (UCMS) in mice. Mice were administered mixed grain or FG for 3 weeks and were then exposed to UCMS for 4 weeks. FG administration ameliorated stress-induced anxiety/despair-like behavior. FG administration also prevented UCMS-induced memory impairment. Additionally, the mRNA levels of 5-HTR1A and IL-6 were restored to normal levels in the brains of FG-administered mice. FG administration also inhibited intestinal damage in stressed mice compared with that in the UCMS (without FG) group. These results suggest that FG can alleviate stress-induced intestinal damage, brain dysfunction, and cognitive impairment.
- Publication
Food Science & Biotechnology, 2024, Vol 33, Issue 4, p969
- ISSN
1226-7708
- Publication type
Article
- DOI
10.1007/s10068-023-01387-x