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- Title
Higher expression of CDKN2A gene is potential prognostic marker for clear cell renal cell carcinoma.
- Authors
Tawedrous, Eriny; Wala, Samantha; Saleeb, Rola; Rotondo, Fabio; Qiang Ding; Yousef, George M.
- Abstract
Objective: We aim to investigate the expression of CDKN2A gene by immunohistochemistry and correlate its expression with the prognosis in clear cell renal cell carcinoma. Methods: We investigated the prognostic value of the cyclindependent kinase inhibitor 2A (CDKN2A) gene expression, which is encoded on chromosome 9p21, in 294 primary ccRCC cases by immunohistochemistry on tissue microarray. We compared its expression with clinicopathologic parameters and patients' survival. We also validated our results at the mRNA level on an independent set (415) from The Cancer Genome Atlas (TCGA). Data and Results: There was a significant association between CDKN2A expression and tumour size, with higher expression associated with smaller tumour size (p < 0.001). As a dichotomous variable (positive vs. negative expression), there was a significant association between CDKN2A expression and tumour grade, with positive expression associated with lower tumour grades (p < 0.001). In the univariate analysis, positive expression was associated with significantly longer disease-free survival (HR= 0.46; p = 0.006). This was maintained in the multivariate analysis (HR= 0.44; p = 0.005). Kaplan-Meier survival analyses showed that positive CDKN2A expression was associated with statistically significant increase in disease-free survival (p = 0.007). We independently validated our results on 415 patients from the TCGA cohort which similarly showed a significant increase of the overall survival with higher CDKN2A expression levels (P = 0.04). Conclusions: Our results indicated that CDKN2A is a potential prognostic marker for ccRCC that may give clinicians an extra tool to guide individual patient's management.
- Publication
Canadian Journal of Pathology, 2016, Vol 8, p37
- ISSN
1918-915X
- Publication type
Article