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- Title
Common inflammatory biomarkers of cancer prognosis.
- Authors
Wan, Bo Angela; Lam, Michael; Furfari, Anthony; McDonald, Rachel; Rowbottom, Leigha; Chan, Stephanie; Zaki, Pearl; DeAngelis, Carlo; Chow, Ronald; Charames, George S.; Lam, Henry; Chow, Edward; Azad, Azar
- Abstract
Biomarkers have the potential to act as important tools in predicting prognosis of cancer patients. Blood is one of the most readily available sources of biomarkers. In addition to being easy to obtain, levels of the protein and cell constituents in blood provide valuable information regarding the degree of inflammation. Inflammatory proteins, leukocyte levels, and platelet levels may be able to predict survival in many cancer types. The present selective review summarizes the currently available literature reporting on common inflammatory blood biomarkers, excluding cytokines and chemokines, and their association with prognosis in cancer patients. A literature search was conducted on Medline and Embase utilizing keywords such as 'neoplasm,' 'inflammation,' 'biomarker,' 'allele,' and 'genomics.' Articles that reported on the levels of commonly implemented prognostic biomarkers (C reactive protein (CRP), albumin, white blood cell and platelet counts) and their derivative scores or ratios relating to prognosis were selected for inclusion. Information regarding the patient population, cancer type, interventions received, type of biomarker, and the impact on prognosis was extracted from each of the 23 studies included in this review. The most commonly reported biomarker was neutrophil-lymphocyte ratio, which was found to be significant across 12 studies spanning at least 6 different types of malignancies. Blood biomarkers associated with inflammation are a common prognostic tool due to the ease of blood sampling and its widespread significance across a range of cancers.
- Subjects
BIOMARKERS; BLOOD testing; CANCER patients; INFLAMMATION; LEUCOCYTES; MEDLINE; PROGNOSIS; PROTEINS; TUMORS; LITERATURE reviews; DATA analysis software; ODDS ratio
- Publication
Journal of Pain Management, 2017, Vol 10, Issue 3, p299
- ISSN
1939-5914
- Publication type
Article