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- Title
Genetic biomarkers of cancer prognosis.
- Abstract
Prognosis after a cancer diagnosis ranges widely depending on the type of cancer, as well as on individual characteristics of the tumour and patient. Historically, most biomarkers used clinically have been biologically based; however, the genetic revolution of the last decade has spurred the investigation and discovery of numerous genetic biomarkers, which relate to aspects of DNA or RNA that are associated with cancer prognosis. We conducted a select review that summarizes the currently available literature reporting on genetic biomarkers and their association with prognosis in cancer patients. A literature search was conducted on Medline and Embase utilizing keywords such as "cancer", "inflammation", "prognosis", and "biomarkers". Articles that reported on genetic biomarkers relating to prognosis were selected for inclusion. Information regarding patient population, cancer type, interventions received, type of genetic marker (i.e. DNA or RNA), and the impact on prognosis was extracted. A total of 18 studies were included in this select review. Nine studies reported on DNA biomarkers relating to prognosis and the remaining 9 studies investigated RNA biomarkers of prognosis. A large amount of literature exists on the association of genetic polymorphisms and gene expression with cancer prognosis. As the number of cancer diagnoses is only expected to increase, genetic biomarkers associated with enhanced or poorer overall survival may have clinical utility and meaning to both oncologists and patients alike.
- Subjects
BIOMARKERS; CANCER patients; DNA; GENETIC polymorphisms; GENETICS; MEDICAL information storage &; retrieval systems; MEDLINE; NUCLEOTIDES; PROGNOSIS; RNA; TUMORS; GENETIC markers; GENOMICS; DATA analysis software
- Publication
Journal of Pain Management, 2017, Vol 10, Issue 3, p319
- ISSN
1939-5914
- Publication type
Article