We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Advanced case of PKDL due to delayed treatment: A rare case report.
- Authors
Topno, Roshan Kamal; Rabi Das, Vidya Nand; Kumar, Maneesh; Madhukar, Major; Pandey, Krishna; Verma, Neena; Agrawal, Kanhaiya; Lal, Chandra Shekhar; Siddiqui, Niyamat Ali; Bimal, Sanjiva; Das, Pradeep
- Abstract
Post-kala-azar dermal leishmaniasis (PKDL) is clinical outcome of visceral leishmaniasis (VL) and is thought to be the potential reservoir of parasite. Miltefosine (MF) is the only oral drug existing for treatment of post-kala-azar dermal leishmaniasis (PKDL). Increased miltefosine tolerance in clinical isolates of Leishmania donovani has been reported and is one of the major concerns in the treatment of PKDL. Here, we report a highly ulcerated PKDL case that was successfully cured after miltefosine treatment. Author summary: Post-kala-azar dermal leishmaniasis (PKDL) is a dermatological complication which usually occurs among treated VL cases. Despite active surveillance, some exclusive cases have been reported in the areas where VL is endemic. To eliminate VL, all source of reservoir to be managed properly. The appropriate diagnosis and treatment of PKDL cases are key. Here we report the identification and treatment of a highly ulcerated PKDL case. A detailed investigation inferred the possible role of CD8 + T cell in the skin ulcer. This report also describes how to identify the suspected case, to confirm the diagnosis, and to provide a successful treatment option.
- Subjects
VISCERAL leishmaniasis; LEISHMANIA donovani; LEISHMANIASIS; T cells
- Publication
PLoS Neglected Tropical Diseases, 2020, Vol 14, Issue 3, p1
- ISSN
1935-2727
- Publication type
Article
- DOI
10.1371/journal.pntd.0008052