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- Title
Deletion of beta-2-microglobulin ameliorates spinal cord lesion load and promotes recovery of brainstem NAA levels in a murine model of multiple sclerosis.
- Abstract
The article discusses a study which examines the role of CD8+ T cells in spinal cord pathology, axonal injury, and brain stem N-acetyl aspartate (NAA) levels during acute and chronic phases of Theiler's murine encephalomyelitis virus (TMEV)-induced demyelination in mice. Magnetic resonance spectroscopy was used to determine beta-2-microglobulin in mice. The study found that NAA levels are influenced by spinal cord integrity but not brain stem pathology.
- Subjects
MICROGLOBULINS; T cells; SPINAL cord diseases; BRAIN stem diseases; LABORATORY mice; ASPARTATES; THEILER'S murine encephalomyelitis virus; DEMYELINATION
- Publication
Current Medical Literature: Multiple Sclerosis, 2012, Vol 4, Issue 4, p104
- ISSN
2041-2177
- Publication type
Article