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- Title
Effect of Alpha-interferon on Natural Killer Cell Activity and Lymphocyte Subsets in Thalassemia Patients with Chronic Hepatitis C.
- Authors
Malaponte, Graziella; Passero, Enrica; Leonardi, Salvatore; Monte, Vincenzo; Lauria, Carmela; Mazzarino, Clorinda; Sciotto, Antonella; Mancuso, Giovanna Russo; Di Gregorio, Felicia; Musumeci, Salvatore
- Abstract
The variation of natural killer (NK) cell activity and lymphocyte subsets 20 h after a single test dose of α-IFN, was studied in 17 thalassemic patients with chronic hepatitis C. All patients had suspended the α-IFN therapy at least 12 months before the study: 10 were considered responders and 7 nonresponders. Also NK cell cytotoxicity after in vitro incubation with α-IFN was studied. The administration of a single dose of α-IFN increased NK cell cytotoxic activity significantly in the group of responders and in non-responders; moreover the NK cell cytotoxic activity after α-IFN in vitro incubation increased both in responders and nonresponders, but to a lesser degree than in healthy controls. Absolute values of CD4+ and CD8+ lymphocytes decreased significantly only in responders. In conclusion, our data suggest that the variation of NK cytotoxic activity and lymphocyte subsets after a test dose of α-IFN can be considered a parameter related to IFN biological effects. Copyright © 1997 S. Karger AG, Basel
- Publication
Acta Haematologica, 1997, Vol 98, Issue 2, p83
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000203603