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- Title
Inflammatory Markers and Cytokines in Moderate and Critical Cases of COVID-19.
- Authors
Soon Hee Chang; Dohsik Minn; Shin-Woo Kim; Yu Kyung Kim
- Abstract
Background: Inflammatory responses have been suggested to be associated with coronavirus disease 2019 (COVID-19). This study investigated the inflammatory markers and cytokines in COVID-19 according to its severity. Methods: We enrolled 49 patients with COVID-19, who were classified as either moderate or critical cases. Serum or plasma interleukin (IL)-1β, IL-6, and tumor necrosis factor-𝛂 (TNF-𝛂) levels were measured. Results: Lactate dehydrogenase, ferritin, C-reactive protein, and procalcitonin levels were significantly higher in the critical group than in the moderate group (p < 0.001). IL-6 and TNF-𝛂 levels were significantly higher in the critical group, with elevated IL-6 levels from the first to third weeks after confirmed PCR (p < 0.05). Conclusions: Inflammatory markers and cytokines were increased in COVID-19 and closely related to the severity of the disease. We recommend early active monitoring of IL-6 levels along with inflammatory markers for severe COVID-19.
- Subjects
COVID-19 pandemic; COVID-19; CALCITONIN; CYTOKINES; LACTATE dehydrogenase; C-reactive protein
- Publication
Clinical Laboratory, 2021, Issue 9, p2115
- ISSN
1433-6510
- Publication type
Article
- DOI
10.7754/Clin.Lab.2021.210142