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- Title
Pan-cancer analysis of PSCA that is associated with immune infiltration and affects patient prognosis.
- Authors
Wang, Chenxing; Zhu, Xingjia; Zheng, Ming; Chen, Yixun; Jiang, Rui; He, Xinyi; Liu, Zongheng; Lu, Zhichao; Wang, Ziheng; Yang, Yang
- Abstract
Prostate stem cell antigen (PSCA) is associated with disease progression, promotion of angiogenesis, invasion, metastasis and immune evasion in cancer. However, its expression pattern and diagnostic and prognostic potential have not been thoroughly analysed from a pan-cancer perspective. This study aimed to examine the effects of PSCA on the prognosis and inflammatory cell infiltration patterns of various cancer types. We analysed the relationship between PSCA expression and immunological subtypes in tumor microenvironment (TME) and the role of molecular subtypes, potentially promising immune biomarkers and tumour-infiltrating lymphocytes (TILs) in various cancer types, especially lung adenocarcinoma (LUAD). In addition, we investigated the prognostic significance of PSCA expression in LUAD. The co-expression network of PSCA was found to be mainly involved in the regulation of immune responses and antigen processing and expression and was significantly enriched in pathological and substance metabolism-related pathways in cancer. Altogether, this study reveals that PSCA is a promising target for immunotherapy in patients with cancer.
- Subjects
IMMUNOREGULATION; TUMOR-infiltrating immune cells; PROGNOSIS; ANTIGEN processing; CELL aggregation
- Publication
PLoS ONE, 2024, Vol 19, Issue 6, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0298469