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- Title
CHELERYTHRINE PREVENTS MICE LIVER FIBROGENESIS INJURY VIA REGULATION OF TGFB/SMADS SIGNAL PATHWAY.
- Authors
XIAOMING LI; HONGLIAN ZHANG; XIAOLI WANG
- Abstract
The aim of the study was to investigate the effect of chelerythrine (CHE) anti-liver fibrosis in mice and the underlying mechanism through regulation of TGFβ/smads signaling pathway. Here, we demonstrate that chelerythrine suppressed the factor expression of CCI4 and BDL induced liver injury markers ALT, AST, HA, Hyp, as well as HSCs activation and ECM deposition. Mechanistically, chelerythrine promoted the concentration of GSH and reduced the content of ROS. Simultaneously, chelerythrine inhibited TGFβ secretion and restrained TβRI, TβRII, smad 3, smad4 expression. Furthermore, chelerythrine prevented the activation of HSCs through TGFβ/smads signaling pathway. Collectively, the data suggested chelerythrine inhibited extracellular matrix formation and alleviated CCl4 and BDL mice liver fibrosis, preventing activation of HSCs, via suppressing oxidative stress and the TGFβ/smads signaling pathway.
- Subjects
FIBROSIS; LIVER injuries; REACTIVE oxygen species; GENE expression; TRANSFORMING growth factors
- Publication
Acta Poloniae Pharmaceutica, 2022, Vol 79, Issue 5, p705
- ISSN
0001-6837
- Publication type
Article
- DOI
10.32383/appdr/144969