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- Title
Covalent Self-Assembly and One-Step Photocrosslinking of Tyrosine-Rich Oligopeptides to Form Diverse Nanostructures.
- Authors
Min, Kyoung-Ik; Yun, Gyeongwon; Jang, Yoonjung; Kim, Kyung-Rok; Ko, Young Ho; Jang, Hyung-Seok; Lee, Yoon-Sik; Kim, Kimoon; Kim, Dong-Pyo
- Abstract
We present covalently self-assembled peptide hollow nanocapsule and peptide lamella. These biomimetic dityrosine peptide nanostructures are synthesized by one-step photopolymerization of a tyrosine-rich short peptide without the aid of a template. This simple approach offers direct synthesis of fluorescent peptide nanocages and free-standing thin films. The simple crosslinked peptide lamella films provide robust mechanical properties with an elastic modulus of approximately 30 GPa and a hardness of 740 MPa. These nanostructures also allow for the design of peptidosomes. The approach taken here represents a rare example of covalent self-assembly of short peptides into nano-objects, which may be useful as microcompartments and separation membranes.
- Subjects
PEPTIDES; NANOCAPSULES; NANOSTRUCTURES; PHOTOPOLYMERIZATION; PHOTOCROSSLINKING
- Publication
Angewandte Chemie International Edition, 2016, Vol 55, Issue 24, p6925
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201601675