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- Title
The Impact of Di(2-ethylhexyl)phthalate on Cancer Progression.
- Authors
Chou, Chon-Kit; Yang, Ya-Ting; Yang, Ho-Chun; Liang, Shih-Shin; Wang, Tsu-Nai; Kuo, Po-Lin; Wang, Hui-Min David; Tsai, Eing-Mei; Chiu, Chien-Chih
- Abstract
Di(2-ethylhexyl)phthalate (DEHP), a widely used plasticizer, mainly serves as an additive to render polyvinyl chloride (PVC) soft and flexible. PVC plastics have become ubiquitous in our modern society. Yet, the leaching of DEHP from PVC-based consumables ultimately results in the deposition in certain tissues via inadvertent applications. Health risks for human populations exposed to DEHP has been assumed by studies on rodents and other species, including the DEHP-induced developmental dysregulation, reproductive impairments, tumorigenesis, and diseases in a transgenerational manner. In this review, we comprehensively summarize the accumulated literature regarding the multifaceted roles of DEHP in the activation of the nuclear receptors, the alteration of the redox homeostasis, epigenetic modifications and the acquisition of chemoresistance.
- Publication
Archivum Immunologiae & Therapiae Experimentalis, 2018, Vol 66, Issue 3, p183
- ISSN
0004-069X
- Publication type
Article
- DOI
10.1007/s00005-017-0494-2