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- Title
IgA is the predominant isotype of anti-β2 glycoprotein I in patients with COVID-19.
- Authors
Melayah, Sarra; Omrani, Nouha; Alouini, Hela; Ghozzi, Mariam; Mrad, Sawssen; Boussarsar, Mohamed; Chaouch, Houda; Hachfi, Wissem; Letaief, Amel; Mankaï, Amani; Ghedira, Ibtissem
- Abstract
Objective The aim of this research was to determine the frequency of antiphospholipid antibodies (aPL) in patients with COVID-19. Methods The frequency and titers of anticardiolipin antibodies (aCL) and anti-β2 glycoprotein I antibodies (aβ2GPI) were determined in sera of adult patients hospitalized with COVID-19. Immunoglobulin (Ig)G, IgA, IgM aCL, and aβ2GPI were measured using enzyme-linked immunosorbent assay. Results Eighty-three patients were included in the study. The mean age of patients was 62 ± 13.9 years, ranging from 23 to 86 years. Stratification according to severity of infection divided patients in 2 groups: 45 patients with moderate infection and 38 patients with critical or severe infection. Out of the 83 patients suffering from COVID-19, aPL (aCL or aβ2GPI) were detected in 24 patients (28.9%). IgG, IgA and IgM aβ2GPI were positive in 2.4%, 16.9% and 8.4%, respectively. IgG, IgA and IgM aCL showed positivity in 7.2%, 0%, and 4.8%, respectively. The frequency of aPL was 36.8% in patients with critical/severe infection and 22.2% in patients with moderate infection. In critical/severe patients, the frequency of aβ2GPI was significantly higher than aCL (34.2% vs 13.2%, P =.03) and aβ2GPI-IgA were significantly more frequent than aβ2GPI-IgG (21.1% vs 2.6%, P =.028). Conclusion In this cross-sectional study, aPL and particularly aβ2GPI-IgA were common in patients with COVID-19.
- Subjects
TUNISIA; CROSS-sectional method; OXYGEN saturation; PNEUMONIA; LEUKOCYTE count; ADULT respiratory distress syndrome; PLATELET count; AUTOANTIBODIES; IMMUNOGLOBULINS; HEMOGLOBINS; PROTHROMBIN time; ASPARTATE aminotransferase; ENZYME-linked immunosorbent assay; FISHER exact test; GLYCOPROTEINS; BILIRUBIN; FIBRIN fibrinogen degradation products; DESCRIPTIVE statistics; CHI-squared test; MANN Whitney U Test; INTENSIVE care units; ALANINE aminotransferase; COMPARATIVE studies; DATA analysis software; COVID-19; C-reactive protein; BIOMARKERS; SPECTROPHOTOMETRY
- Publication
Laboratory Medicine, 2024, Vol 55, Issue 3, p373
- ISSN
0007-5027
- Publication type
Article
- DOI
10.1093/labmed/lmad097