We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Analysis of Multiple Bands on Serum Protein Immunofixation Electrophoresis: Challenge in Interpretation of Clonality in a Patient with Light Chain–Predominant Multiple Myeloma.
- Authors
Nwogbo, Okechukwu V; Jin, Yulan; Sliker, Taylor; Wilhite, Dorian; Singh, Gurmukh
- Abstract
Sera from patients with multiple myeloma usually display a single monoclonal immunoglobulin band on serum protein immunofixation electrophoresis. Multiple bands may be seen if the myeloma is bi- or triclonal or if the monoclonal immunoglobulin has rheumatoid factor activity. We describe a patient with light chain–predominant IgA lambda myeloma; the patient's serum displayed 2 spatially distinct bands reacting for alpha heavy and lambda light chains. The methods used to establish monoclonality are addressed.
- Subjects
IMMUNOELECTROPHORESIS; AUTOANTIBODIES; IMMUNOGLOBULINS; STAINS &; staining (Microscopy); BLOOD protein electrophoresis; PANCYTOPENIA; CHROMOSOME abnormalities; FLUORESCENCE in situ hybridization; MULTIPLE myeloma; GENETIC techniques
- Publication
Laboratory Medicine, 2021, Vol 52, Issue 5, p503
- ISSN
0007-5027
- Publication type
Article
- DOI
10.1093/labmed/lmab001