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- Title
Multi-Level Logic Gate Operation Based on Amplified Aptasensor Performance.
- Authors
Feng, Lingyan; Lyu, Zhaozi; Offenhäusser, Andreas; Mayer, Dirk
- Abstract
Conventional electronic circuits can perform multi-level logic operations; however, this capability is rarely realized by biological logic gates. In addition, the question of how to close the gap between biomolecular computation and silicon-based electrical circuitry is still a key issue in the bioelectronics field. Here we explore a novel split aptamer-based multi-level logic gate built from INHIBIT and AND gates that performs a net XOR analysis, with electrochemical signal as output. Based on the aptamer-target interaction and a novel concept of electrochemical rectification, a relayed charge transfer occurs upon target binding between aptamer-linked redox probes and solution-phase probes, which amplifies the sensor signal and facilitates a straightforward and reliable diagnosis. This work reveals a new route for the design of bioelectronic logic circuits that can realize multi-level logic operation, which has the potential to simplify an otherwise complex diagnosis to a 'yes' or 'no' decision.
- Subjects
ELECTRONIC circuits; BIOELECTRONICS; BIOMOLECULAR electronics; APTAMERS; RECTIFICATION (Electricity); ELECTRIC current rectifiers
- Publication
Angewandte Chemie International Edition, 2015, Vol 54, Issue 26, p7693
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201502315