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- Title
The development of Lhermitte's sign during cisplatin chemotherapy. Possible drug-induced toxicity causing spinal cord demyelination.
- Authors
Walther, Philip J.; Jr, Eugene Rossitch; Bullard, Dennis E.; Walther, P J; Rossitch, E Jr; Bullard, D E
- Abstract
Cisplatin is a recognized neurotoxic agent that commonly causes ototoxicity and peripheral neuropathy. In conjunction with characteristic peripheral neuropathy, two patients treated with high-dose cisplatin developed Lhermitte's sign, a manifestation of posterior column spinal cord pathology. After cisplatin therapy was stopped, this symptom gradually resolved. This suggests that at high doses cisplatin may also cause demyelinating central nervous system lesions involving the spinal cord.
- Publication
Cancer (0008543X), 1987, Vol 60, Issue 9, p2170
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19871101)60:9<2170::AID-CNCR2820600909>3.0.CO;2-N