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- Title
Imaging of human brain lesions with an omega 3 site radioligand.
- Authors
Benavides, J; Cornu, P; Dennis, T; Dubois, A; Hauw, J J; MacKenzie, E T; Sazdovitch, V; Scatton, B
- Abstract
The topography and magnitude of increase in peripheral type benzodiazepine binding sites (omega 3 sites) was investigated autoradiographically in the brains of patients with ischemic cerebrovascular disease, with multiple sclerosis, and with malignant glioma. 3H-PK 11195, a selective omega 3 site ligand, was employed. A manyfold increase in omega 3 site density was observed in all these disease states; this increase reflects macrophage invasion or glial proliferation or both as demonstrated by neuropathological studies carried out in parallel. There was an excellent spatial correlation between increased omega 3 site densities and extent of the lesion histologically. Specifically, an elevated density of omega 3 sites was observed in the plaques of demyelination in multiple sclerosis patients, in the periphery of infarcted zones in stroke patients, and throughout tumor in patients with grade IV astrocytomas. As our approach is applicable to both tomographic (in vivo) and autoradiographic investigations, imaging of omega 3 sites may be considered for the detection and monitoring of the natural evolution of many disorders of the human central nervous system.
- Subjects
BRAIN; BRAIN tumors; CELL receptors; CEREBRAL ischemia; GLIOMAS; ISOQUINOLINE; MULTIPLE sclerosis; RADIOGRAPHY; RADIOISOTOPES in medical diagnosis
- Publication
Annals of Neurology, 1988, Vol 24, Issue 6, p708
- ISSN
0364-5134
- Publication type
journal article