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- Title
The relation of fragmented QRS with tissue Doppler derived parameters in patients with b-thalassaemia major.
- Authors
Buyukkaya, Eyup; Karakas, Mehmet Fatih; Kurt, Mustafa; Bilen, Perihan; Yalcin, Fatih; Celik, Murat; Helvaci, Rami; Kaya, Hasan; Ertekin, Filiz; Sökmen, Erdogan; Sen, Nihat; Akcay, Adnan Burak; Yalcın, Fatih; Helvacı, Rami
- Abstract
<bold>Purpose: </bold>The most important complication encountered in patients with b-thalassaemia major is degenerative fibrosis developing as a result of iron accumulation in myocardial tissue. Dysfunction pursues this accumulation. Recently, presence of fragmented QRS (fQRS) in ECG has been regarded as a predictor of myocardial fibrosis. We aimed in our study to investigate the frequency with which fQRS develops in patients with b-thalassaemia major and to disclose the correlation between fQRS frequency and Doppler-derived indices.<bold>Methods: </bold>The patients with b-thalassaemia major (n=66; mean age: 23±6 years) and healthy controls (n=30; mean age: 23±4 years) were included. fQRS pattern was described as presence of RSR' manifested as existence of additional R wave and notching in either R or S waves in ECG recordings. 2D, M-mode, conventional Doppler, tissue Doppler echocardiography parameters were assessed. Mean serum ferritin levels over past 5 years were also calculated.<bold>Results: </bold>When compared to those in control group, fQRS was more frequent in b-thalassaemia major group, indicating statistical significance (p = 0.001). While E/Em and ferritin level exhibited statistically significant increase in thalassaemia patients with fQRS (p < 0.05), the mean Em and Sm values were found to be significantly low (p < 0.05).<bold>Conclusions: </bold>fQRS was frequently observed in the patients with b-thalassaemia major, which was of statistical significance. Tissue Doppler-derived diastolic and systolic indices in thalassaemia cases with fQRS showed statistically significant impairment compared to those without fQRS. In conclusion, fQRS may represent a novel noninvasive marker for cardiac involvement in patients with b-thalassaemia major.
- Publication
Clinical & Investigative Medicine, 2012, Vol 35, Issue 5, pE334
- ISSN
0147-958X
- Publication type
journal article
- DOI
10.25011/cim.v35i5.18707