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- Title
Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.
- Authors
Gudmundsson, Julius; Sulem, Patrick; Rafnar, Thorunn; Bergthorsson, Jon T; Manolescu, Andrei; Gudbjartsson, Daniel; Agnarsson, Bjarni A; Sigurdsson, Asgeir; Benediktsdottir, Kristrun R; Blondal, Thorarinn; Jakobsdottir, Margret; Stacey, Simon N; Kostic, Jelena; Kristinsson, Kari T; Birgisdottir, Birgitta; Ghosh, Shyamali; Magnusdottir, Droplaug N; Thorlacius, Steinunn; Thorleifsson, Gudmar; S Lilly Zheng
- Abstract
We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 × 10−13 and 7.7 × 10−9, respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease.
- Subjects
ICELAND; GENOMICS; GENOMES; PROSTATE cancer; CANCER genetics; GENETICS
- Publication
Nature Genetics, 2008, Vol 40, Issue 3, p281
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.89