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- Title
Peripheral T Cell Lymphomas: An Immunological Study of Seven Unusual Cases.
- Authors
Raziuddin, S.; Latif, A. B. A.; Arif, S.; Ahad, A.; Zaidi, A. Z.
- Abstract
A multiparameter study of malignant lymph node cells and peripheral blood lymphocytes of seven patients with peripheral T cell lymphoma is presented. The results of monoclonal marker studies showed three cases of helper-suppressor T cell lymphoma (OKT4+, OKT8+), one case of suppressor T cell lymphoma (OKT8+), and three cases of helper T cell lymphoma (OKT4+), Immunophenotypic heterogeneity of neoplastic T cells with expression of pan-T antigens, OKT3+, and OKT11+ (erythroeyte rosetting+) was observed in most patients. Six of the seven cases tested showed la and DR antigens. No relationship was detected between patterns of reactivity with T cell reagents and histological types. When tested, the in-vitro malignant T cells of five patients proliferated in response to concanavalin A (Con A), but had poor response to phytohaemagglutinin. The interleukin 2 receptors showed maximum expression on Con A-activated T cells of five patients, and phytohaemagglutinin-activated T cells of one patient. The neoplastic T cells (OKT4+, OKT8+) of one patient studied had suppressor activity for IgG and IgA, and helper activity for IgM synthesis on pokeweed mitogen-induced normal B cell differentiations.
- Subjects
T cells; LYMPHOMAS; LYMPH nodes; LYMPHOCYTES; MONOCLONAL antibodies; ANTIGENS; IMMUNOGLOBULIN M
- Publication
Scandinavian Journal of Immunology, 1988, Vol 27, Issue 5, p495
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1988.tb02376.x