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- Title
Differentiation by Interleukin 2 of a Subpopulation of Human B Cells.
- Authors
Grillot-Courvalin, C.; Labaume, S.; Brouet, J.-C.
- Abstract
We demonstrate here that purified recombinant interleukin 2 (IL-2) induces a sizeable population of highly purified spleen B cells, by both negative and positive (cell-sorting) selection to differentiate polyclonally into plasma cells. This effect is seen at concentrations of IL-2 that are optimal for T-cell growth (1-5 U/ml) and is inhibitable by anti-Tac monoclonal antibody. In contrast, peripheral blood B cells show no or minimal terminal differentiation. When spleen B cells were separated into small and large cells, only the latter responded to IL-2; since this state of activation is achieved in vivo, these data support the possibility that IL-2 may be a physiological mediator in B-cell differentiation.
- Subjects
LYMPHOID tissue; LYMPHOCYTES; IMMUNOGLOBULINS; MOLECULAR cloning; MONOCLONAL antibodies; B cells
- Publication
Scandinavian Journal of Immunology, 1986, Vol 23, Issue 6, p679
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1986.tb02004.x