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- Title
Con A-induced Suppressor Cell Activity and T-lymphocyte Subpopulations in Peripheral Blood Lymphocytes of Patients with Rheumatoid Arthritis and Juvenile Rheumatoid Arthritis.
- Authors
Dobloug, J. H.; Chattopadhyay, C.; Førre, Ø.; Høyeraal, H. M.; Natvig, J. B.
- Abstract
Suppressor cell activity was investigated in peripheral blood lymphocytes from twenty patients with rheumatoid arthritis (RA) and twenty patients with juvenile rheumatoid arthritis (JRA) using a concanavalin A/mixed lymphocyte culture assay. The mean suppression in the RA patients was slightly reduced compared with the suppressor cell activity in adult controls (25±5% suppression compared with 37±5%; P>0.05, Student's t test), whereas the JRA patients had normal suppressor cell activity (mean 46±5% versus 43±5% in healthy children matched for age and sex). The RA patients had normal proportions of T-cell subpopulations, 13.3% Ty cells and 49.8% Tμ cells, compared with 13.8% and 58.0% in controls. The JRA patients, however, had a significantly reduced mean percentage of Tγ cells, 6.6%, compared with 13.8% in healthy children (P<0.05, Mann-Whitney U-test). The mean percentage of Tμ cells was 53.7%, versus 56.2% in the controls. The relation between suppressor cell activity and suppressor cells enumerated by membrane markers is discussed.
- Subjects
SUPPRESSOR cells; RHEUMATOID arthritis; AUTOIMMUNE diseases; LYMPHOCYTES; IMMUNOLOGY
- Publication
Scandinavian Journal of Immunology, 1981, Vol 13, Issue 4, p367
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1981.tb00146.x