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- Title
Neutrophil: lymphocyte ratio is positively related to type 2 diabetes in a large-scale adult population: a Tianjin Chronic Low-Grade Systemic Inflammation and Health cohort study.
- Authors
Xiaoyan Guo; Shu Zhang; Qing Zhang; Li Liu; Hongmei Wu; Huanmin Du; Hongbin Shi; Chongjin Wang; Yang Xia; Xing Liu; Chunlei Li; Shaomei Sun; Xing Wang; Ming Zhou; Guowei Huang; Qiyu Jia; Honglin Zhao; Kun Song; Kaijun Niu
- Abstract
Aim: It is widely known that inflammation is related to type 2 diabetes (T2D), but few studies have shown a direct relationship between the immune system and T2D using a reliable biomarker. Neutrophil:lymphocyte ratio (NLR) is an easy-to-analyze c inflammation biomarker, but few studies have assessed the relationship between NLR and T2D. In order to evaluate how NLR ti is related to T2D, we designed a large-scale cross-sectional and prospective cohort study in an adult population. Subjects and methods: Participants were recruited from the Tianjin Medical University General Hospital-Health Management Centre. Both a baseline cross-sectional (n = 87 686) and a prospective (n = 38 074) assessment were performed. Participants without a history of T2D were followed up for ~6 years (with a median follow-up of 2.7 years). Adjusted logistic and Cox proportional hazards regression models were used to assess relationships between the quintiles of NLR and T2D (covariates: age, sex, BMI, smoking status, drinking status, hypertension, hyperlipidemia, and family history of cardiovascular disease, hypertension, hyperlipidemia, or diabetes). Results: The prevalence and incidence of T2D were 4.9% and 6.8/1000 person-years respectively. The adjusted odds ratio and hazard ratio (95% CI) of the highest NLR quintile were 1.34 (1.21, 1.49) and 1.39 (1.09, 1.78) (both P for trend <0.01) respectively as compared to the lowest quintile of NLR. Leukocyte, neutrophil, and lymphocyte counts do not significantly predict the eventual development of T2D. Conclusion: The present study demonstrates that NLR is related to the prevalence and incidence of T2D, and it suggests that NLR may be an efficient and accurate prognostic biomarker for T2D.
- Subjects
TYPE 2 diabetes treatment; NEUTROPHILS; LYMPHOCYTES; BIOMARKERS; INFLAMMATION; COHORT analysis
- Publication
European Journal of Endocrinology, 2015, Vol 173, Issue 2, p217
- ISSN
0804-4643
- Publication type
Article
- DOI
10.1530/EJE-15-0176