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- Title
Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection.
- Authors
Ritchie, Adam John; Fangping Cai; Smith, Nicola M. G.; Sheri Chen; Hongshuo Song; Brackenridge, Simon; Abdool Karim, Salim S.; Korber, Bette T.; McMichael, Andrew J.; Feng Gao; Goonetilleke, Nilu
- Abstract
Background A major immune evasion mechanism of HIV-1 is the accumulation of non-synonymous mutations in and around T cell epitopes, resulting in loss of T cell recognition and virus escape. Results Here we analyze primary CD8+ T cell responses and virus escape in a HLA B*81 expressing subject who was infected with two T/F viruses from a single donor. In addition to classic escape through non-synonymous mutation/s, we also observed rapid selection of multiple recombinant viruses that conferred escape from T cells specific for two epitopes in Nef. Conclusions Our study shows that recombination between multiple T/F viruses provide greater options for acute escape from CD8+ T cell responses than seen in cases of single T/F virus infection. This process may contribute to the rapid disease progression in patients infected by multiple T/F viruses.
- Subjects
RECOMBINANT viruses; CD80 antigen; HIV infections; T cells; EPITOPES; DISEASE progression
- Publication
Retrovirology, 2014, Vol 11, Issue 1, p2
- ISSN
1742-4690
- Publication type
Article
- DOI
10.1186/s12977-014-0069-9