We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Optimal design and validation of antiviral siRNA for targeting HIV-1.
- Authors
Naito, Yuki; Nohtomi, Kyoko; Onogi, Toshinari; Uenishi, Rie; Ui-Tei, Kumiko; Saigo, Kaoru; Takebe, Yutaka
- Abstract
We propose rational designing of antiviral short-interfering RNA (siRNA) targeting highly divergent HIV-1. In this study, conserved regions within HIV-1 genomes were identified through an exhaustive computational analysis, and the functionality of siRNAs targeting the highest possible conserved regions was validated. We present several promising antiviral siRNA candidates that effectively inhibited multiple subtypes of HIV-1 by targeting the best conserved regions in pandemic HIV-1 group M strains.
- Subjects
AIDS; RNA; GENOMICS; HIV; ANTIVIRAL agents; GENOMES
- Publication
Retrovirology, 2007, Vol 4, p80
- ISSN
1742-4690
- Publication type
Article
- DOI
10.1186/1742-4690-4-80