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- Title
Aquaporins: Gatekeepers of Fluid Dynamics in Traumatic Brain Injury.
- Authors
Czyżewski, Wojciech; Litak, Jakub; Sobstyl, Jan; Mandat, Tomasz; Torres, Kamil; Staśkiewicz, Grzegorz
- Abstract
Aquaporins (AQPs), particularly AQP4, play a crucial role in regulating fluid dynamics in the brain, impacting the development and resolution of edema following traumatic brain injury (TBI). This review examines the alterations in AQP expression and localization post-injury, exploring their effects on brain edema and overall injury outcomes. We discuss the underlying molecular mechanisms regulating AQP expression, highlighting potential therapeutic strategies to modulate AQP function. These insights provide a comprehensive understanding of AQPs in TBI and suggest novel approaches for improving clinical outcomes through targeted interventions.
- Subjects
BRAIN injuries; FLUID dynamics; AQUAPORINS; CEREBRAL edema; GATEKEEPERS
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 12, p6553
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25126553