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- Title
MicroRNAs as the critical regulators of tyrosine kinase inhibitors resistance in lung tumor cells.
- Authors
Maharati, Amirhosein; Zanguei, Amir Sadra; Khalili-Tanha, Ghazaleh; Moghbeli, Meysam
- Abstract
Lung cancer is the second most common and the leading cause of cancer related deaths globally. Tyrosine Kinase Inhibitors (TKIs) are among the common therapeutic strategies in lung cancer patients, however the treatment process fails in a wide range of patients due to TKIs resistance. Given that the use of anti-cancer drugs can always have side effects on normal tissues, predicting the TKI responses can provide an efficient therapeutic strategy. Therefore, it is required to clarify the molecular mechanisms of TKIs resistance in lung cancer patients. MicroRNAs (miRNAs) are involved in regulation of various pathophysiological cellular processes. In the present review, we discussed the miRNAs that have been associated with TKIs responses in lung cancer. MiRNAs mainly exert their role on TKIs response through regulation of Tyrosine Kinase Receptors (TKRs) and down-stream signaling pathways. This review paves the way for introducing a panel of miRNAs for the prediction of TKIs responses in lung cancer patients. -KaejWjeBjScrmcvzjYuCm Video Abstract
- Subjects
PROTEIN-tyrosine kinase inhibitors; LUNG tumors; LUNGS; MICRORNA; PROTEIN-tyrosine kinases; LUNG cancer
- Publication
Cell Communication & Signaling, 2022, Vol 20, Issue 1, p1
- ISSN
1478-811X
- Publication type
Article
- DOI
10.1186/s12964-022-00840-4