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- Title
Associations of genetic variants of endothelin with cardiovascular complications in patients with renal failure.
- Authors
Chih-Chin Kao; Shih-Ying Cheng; Mei-Yi Wu; Shu-Chen Chien; Hsing-Fang Lu; Yu-Wen Hsu; Yan-Feng Zhang; Mai-Szu Wu; Wei-Chiao Chang; Kao, Chih-Chin; Cheng, Shih-Ying; Wu, Mei-Yi; Chien, Shu-Chen; Lu, Hsing-Fang; Hsu, Yu-Wen; Zhang, Yan-Feng; Wu, Mai-Szu; Chang, Wei-Chiao
- Abstract
<bold>Background: </bold>Cardiovascular (CV) complications are the main cause of death in end-stage renal disease (ESRD) patients. The high CV risks are attributable to the additive effects of multiple factors. Endothelin (EDN) is a potent vasoconstrictor and plays a role in regulating vascular homeostasis. However, whether variants of the EDN gene are associated with risks of CV events is not known. We conducted a study to investigate associations of variants of the EDN gene with CV events in ESRD patients.<bold>Methods: </bold>A cohort of 190 ESRD patients was recruited, and 19 tagged single-nucleotide polymorphisms within the EDN gene family were selected for genotyping through a TaqMan assay. Data on clinical characteristics and hospitalizations for CV events were collected. Associations of genetic variants of the EDN gene with CV events were analyzed.<bold>Results: </bold>In this cohort, 62% (n = 118) of patients were hospitalized for a CV event. The EDN1 rs4714384 (CC/TC vs. TT) polymorphism was associated with an increased risk of a CV event after multiple testing (p < 0.001). Further functional exploration showed that it was a quantitative trait locus which may significantly alter gene expression in the tibial artery.<bold>Conclusions: </bold>EDN1 rs4714384 is very likely an important biomarker of CV events in ESRD patients.
- Subjects
CHRONIC kidney failure complications; CHRONIC kidney failure; CARDIOVASCULAR diseases; PATIENTS; ENDOTHELINS; GENETIC polymorphisms; THERAPEUTICS; GENETICS; GENETIC techniques; LONGITUDINAL method; DISEASE complications
- Publication
BMC Nephrology, 2017, Vol 18, p1
- ISSN
1471-2369
- Publication type
journal article
- DOI
10.1186/s12882-017-0707-2