We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A possible role for CCR5 in the progression of atherosclerosis in HIV-infected patients: a cross-sectional study.
- Authors
Fernández-Sender, Laura; Alonso-Villaverde, Carlos; Rull, Anna; Rodríguez-Gallego, Esther; Riera-Borrull, Marta; Hernández-Aguilera, Anna; Camps, Jordi; Beltrán-Debón, Raúl; Aragonès, Gerard; Menendez, Javier A.; Joven, Jorge
- Abstract
Background: Chemokines can block viral entry by interfering with HIV co-receptors and are recognised mediators of atherosclerosis development. A number of experimental drugs that inhibit HIV entry arrest the development of atherosclerosis in animal models. We hypothesised that the expression of chemokine receptors in circulating leukocytes is associated with the rate of atherosclerosis progression in HIV-infected patients. Methods: The increase in intima-media thickness during a 2-year follow-up was used to classify HIV-infected patients (n = 178) as progressors (n = 142) or non-progressors (n = 36) with respect to atherosclerosis. Logistic regression was used to assess variables associated with atherosclerosis progression. Mutations in the CCR5Δ32, CCR2 64I, and CX3CR1 (T280M and V249I) co-receptors as well as the levels of CCR5, CXCR4, CX3CR1, and CCR2 mRNA expression in circulating leukocytes were analysed as independent variables. Results: Among the baseline variables, only genetic variants explained the dichotomous outcome. The expression of CCR2 and CXCR4 did not discriminate between progressors and non-progressors. Conversely, CCR5 and CX3CR1 expression was higher in not only progressors but also patients with detectable viral load. The logistic regression, however, demonstrated a significant role for CCR5 expression as a predictor of atherosclerosis progression (B = 2.1, OR = 8.1, p = 0.04) and a negligible effect for CXC3R1 and CCR2 expression. Conclusions: Available CCR5 antagonists should be investigated for their potential to delay the course of atherosclerosis in HIV-infected patients.
- Subjects
ATHEROSCLEROSIS; BLOOD vessels; CHEMOKINES; CHI-squared test; EPIDEMIOLOGY; GENE expression; HIV infections; LEUCOCYTES; STATISTICS; T-test (Statistics); LOGISTIC regression analysis; DATA analysis; INTER-observer reliability; CROSS-sectional method; RETROSPECTIVE studies; DATA analysis software; DESCRIPTIVE statistics
- Publication
AIDS Research & Therapy, 2013, Vol 10, p11
- ISSN
1742-6405
- Publication type
Article
- DOI
10.1186/1742-6405-10-11