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- Title
Acute respiratory infections due to enterovirus 68 in Yamagata, Japan between 2005 and 2010.
- Authors
Ikeda, Tatsuya; Mizuta, Katsumi; Abiko, Chieko; Aoki, Yoko; Itagaki, Tsutomu; Katsushima, Fumio; Katsushima, Yuriko; Matsuzaki, Yoko; Fuji, Naoko; Imamura, Tadatsugu; Oshitani, Hitoshi; Noda, Masahiro; Kimura, Hirokazu; Ahiko, Tadayuki
- Abstract
ABSTRACT To clarify the epidemiology of enterovirus 68 (EV68), which is one of the most rarely identified enteroviruses, virus isolation and molecular screening using RT-PCR was performed on 6307 respiratory specimens collected at pediatric clinics in Yamagata, Japan between 2005 and 2010. In the years 2005-2009, 10, 1, 2, 0, and 2 (40) EV68-positive cases, respectively, were identified by RT-PCR. In 2010, 40 cases were identified altogether: 2 by isolation only, 26 by RT-PCR only, and 12 by both isolation and RT-PCR. Phylogenetic analysis indicated that plural genetically distinct clusters co-circulated. These results suggest that that difficulty in EV68 isolation leads to an underestimation of the prevalence of EV68 infections.
- Subjects
YAMAGATA-ken (Japan); JAPAN; RESPIRATORY infections; ENTEROVIRUSES; EPIDEMIOLOGY; VIRUS isolation; REVERSE transcriptase polymerase chain reaction; PEDIATRIC clinics
- Publication
Microbiology & Immunology, 2012, Vol 56, Issue 2, p139
- ISSN
0385-5600
- Publication type
Article
- DOI
10.1111/j.1348-0421.2012.00411.x