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- Title
Comparison of Oncostatin M Expression in Keratoacanthoma and Squamous Cell Carcinoma.
- Authors
Tran, Tien-Anh; Ross, Jeffrey S.; Sheehan, Christine E.; Carlson, J. Andrew
- Abstract
Oncostatin M (OSM) is a 28-kDa glycoprotein, produced by stimulated macrophages and T lymphocytes, that inhibits the proliferation and induces differentiation of a number of different cell lines derived from solid tumors. To determine whether keratoacanthoma (KA) is unique or a variant of squamous cell carcinoma (SCC), we compared the immunohistochemical expression of OSM in the tumor cells and peri- and intratumoral macrophages of 21 mature KAs, 7 regressing KAs, and 27 SCCs. An inverse correlation was identified between OSM tumor labeling and the density of OSM-labeled tumor-associated macrophages for KAs (r = -.4; P = .09). OSM tumor expression was significantly more frequent and more intense in KAs than in SCCs (95% versus 63%; P < .01). In contrast, the density of OSM-labeled macrophages was significantly higher in SCCs compared with mature KAs (7/3 high power fields versus 4/3 high power fields; P = .02). These OSM-positive macrophages were predominantly located at the advancing, infiltrative margins of both neoplasms. Regressing KAs demonstrated a decreased level of OSM tumor expression compared with mature KAs (53% versus 95%; P = .001), but there was no difference in density of OSM-labeled macrophages. Both the above differences and the overlapping patterns of OSM expression suggest that KAs are a variant of SCC where OSM, possibly as an autocrine factor, may mediate KA's overwhelming but not absolute tendency to involute.
- Subjects
KERATOACANTHOMA; SQUAMOUS cell carcinoma; GENE expression; MACROPHAGES; T cells; CELL lines
- Publication
Modern Pathology, 2000, Vol 13, Issue 4, p427
- ISSN
0893-3952
- Publication type
Article
- DOI
10.1038/modpathol.3880073