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- Title
Laminar Distribution of β-Amyloid Deposits in Dementia With Lewy Bodies and Alzheimer's Disease.
- Authors
Armstrong, Richard A.
- Abstract
This study tested whether the laminar distribution of the β-amyloid (Aβ) deposits in dementia with Lewy bodies (DLB) cases with significant Alzheimer's disease (AD) pathology (DLB/AD) was similar to "pure" AD. In DLB/AD, the maximum density of the diffuse and primitive deposits occurred either in the upper laminae or a bimodal distribution was present with density peaks in the upper and lower laminae. A bimodal distribution of the classic Aβ deposits was also observed. Compared with AD, DLB/AD cases had fewer primitive deposits relative to the diffuse and classic deposits; the primitive deposits exhibited a bimodal distribution more frequently, and the diffuse deposits occurred more often in the upper laminae. These results suggest that A~ pathology in DLB/AD may not simply represent the presence of associated AD.
- Subjects
MEDICAL research; LEWY body dementia; DEMENTIA; ALZHEIMER'S disease; AMYLOID beta-protein; NEUROBEHAVIORAL disorders
- Publication
American Journal of Alzheimer's Disease & Other Dementias, 2006, Vol 21, Issue 3, p175
- ISSN
1533-3175
- Publication type
Article
- DOI
10.1177/1533317506289256