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- Title
The 2022 Nobel Prize in Chemistry for the development of click chemistry and bioorthogonal chemistry.
- Authors
Zaia, Joseph
- Abstract
The 2022 Nobel Prize in Chemistry recognized the development of biorthogonal chemical ligation reactions known as click chemistry in biomedicine. This concept has catalyzed significant progress in sensing and diagnosis, chemical biology, materials chemistry, and drug discovery and delivery. In proteomics, the ability to incorporate a click tag into proteins has propelled development of powerful new methods for selective enrichment of protein complexes that inform understanding of protein networks. It also has had a strong influence on the ability to enrich for protein post-translational modifications. This feature article summarizes the impacts of biorthogonal click chemistry on proteomics.
- Subjects
NOBEL Prize in Chemistry; POST-translational modification; LIGATION reactions; DRUG discovery; CHEMICAL biology
- Publication
Analytical & Bioanalytical Chemistry, 2023, Vol 415, Issue 4, p527
- ISSN
1618-2642
- Publication type
Article
- DOI
10.1007/s00216-022-04483-9