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- Title
Direct Metal‐Free Preparation of Functionalizable Polylactic Acid‐Ethisterone Conjugates in a One‐Pot Approach.
- Authors
Luo, Shi‐He; Wu, Yan‐Cheng; Cao, Liang; Lin, Jian‐Yun; Gao, Jian; Chen, Shui‐Xia; Wang, Zhao‐Yang
- Abstract
A series of polylactic acid (PLA) conjugates (PLA‐ES) are synthesized via direct melt polycondensation (DMP) of lactic acid (LA) with ethisterone (ES) in the presence of 0.3 wt% toluenesulfonic acid at 160 °C for 6 h. The drug content of PLA conjugates can be simply adjustable. Further functionalization via Click chemistry is also achieved to extend the biomedicine application of biopolymer based drug delivery. A method for merging polymeric carrier preparation and chemical conjugation into one‐pot, via solvent‐ and metal‐free direct melt polycondensation, for functionalizable polylactic acid‐ethisterone (PLA‐ES) conjugates is developed.
- Subjects
POLYLACTIC acid; BIOCONJUGATES; POLYCONDENSATION; DRUG delivery systems; BIOPOLYMERS
- Publication
Macromolecular Chemistry & Physics, 2019, Vol 220, Issue 5, pN.PAG
- ISSN
1022-1352
- Publication type
Article
- DOI
10.1002/macp.201800475