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- Title
Synthesis and Self-Assembly of Amphiphilic Block Copolymers from Biobased Hydroxypropyl Methyl Cellulose and Poly( l-lactide).
- Authors
Wang, Jielin; Caceres, Marleny; Li, Suming; Deratani, André
- Abstract
A series of well-defined hydroxypropyl methyl cellulose- block-poly( l-lactide) (HPMC- b-PLLA) diblock copolymers are synthesized via UV-initiated thiol-ene click reaction of thiol-terminated HPMC with different block lengths and allyl-terminated PLLA, using 2,2-dimethoxy-2-phenylacetophenone as photocatalyst. The former is obtained by coupling the reducing aldehyde endgroup of short chain HPMC with the amine group of cysteamine, and the latter by ring-opening polymerization of l-lactide in the presence of allyl alcohol. Fourier transform infrared (FT-IR), nuclear magnetic resonance (1H NMR), and diffusion ordered spectroscopy NMR confirm the successful coupling of both blocks. The molar mass of the resulting copolymers ranges from 7000 to 12 800 g mol−1 as determined by size exclusion chromatography. The copolymers are able to self-assemble in aqueous medium, yielding micelles of 50-100 nm with core-shell structure as evidenced by dynamic light scattering, transmission electron microscopy, and 1H NMR. The critical micelle concentration of copolymers ranges from 0.12 to 0.15 mg mL−1. Last but not the least, the copolymers exhibit thermoresponsive behavior with a lower critical solution temperature around 80 °C.
- Subjects
BLOCK copolymers; ACETOPHENONE; PHOTOCATALYSTS; GEL permeation chromatography; FOURIER transform infrared spectroscopy; TRANSMISSION electron microscopy; NUCLEAR magnetic resonance
- Publication
Macromolecular Chemistry & Physics, 2017, Vol 218, Issue 10, pn/a
- ISSN
1022-1352
- Publication type
Article
- DOI
10.1002/macp.201600558