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- Title
Cooperative Photoredox and Cobalt‐Catalyzed Acceptorless Dehydrogenative Functionalization of Cyclopropylamides towards Allylic N,O‐Acyl‐acetal Derivatives.
- Authors
Huang, Haohao; Luan, Xinjun; Zuo, Zhijun
- Abstract
We disclose herein a novel photoredox and cobalt co‐catalyzed ring‐opening/acceptorless dehydrogenative functionalization of mono‐donor cyclopropanes. This sustainable and atom‐economic approach allows the rapid assembly of a wide range of allylic N,O‐acyl‐acetal derivatives. The starting materials are readily available and the reaction features mild conditions, broad substrate scope, and excellent functional group compatibility. The optimized conditions accommodate assorted cycloalkylamides and primary, secondary, and tertiary alcohols, with applications in late‐stage functionalization of pharmaceutically relevant compounds, stimulating further utility in medicinal chemistry. Moreover, selective nucleophilic substitutions with various carbon nucleophiles were achieved in a one‐pot fashion, offering a reliable avenue to access some cyclic and acyclic derivatives.
- Subjects
PHARMACEUTICAL chemistry; FUNCTIONAL groups; NUCLEOPHILES; BIOCHEMICAL substrates; COBALT
- Publication
Angewandte Chemie, 2024, Vol 136, Issue 24, p1
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.202401579