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- Title
A Stereoselective Aldol Approach for the Total Syntheses of Two 6-Alkylated 2 H-Pyran-2-ones.
- Authors
Rajaram, Singanaboina; Ramesh, Dasari; Ramulu, Udugu; Prabhakar, Peddikotla; Venkateswarlu, Yenamandra
- Abstract
A simple and highly efficient stereoselective total synthesis of the 6-alkylated pyranones (6 R)-6-[(1 E,4 R,6 R)-4,6-dihydroxy-10-phenyldec-1-en-1-yl]-5,6-dihydro-2 H-pyran-2-one ( 1) and (6 S)-5,6-dihydro-6-[(2 R)-2-hydroxy-6-phenylhexyl]-2 H-pyran-2-one ( 2) was developed using Crimmins' aldol reaction, SmI2 reduction, Grubbs- II-catalyzed olefin cross-metathesis, and Still's modified Horner Wadsworth Emmons reaction.
- Subjects
STEREOSELECTIVE reactions; PYRANONES synthesis; ALDOLS; METATHESIS reactions; CATALYSIS research
- Publication
Helvetica Chimica Acta, 2014, Vol 97, Issue 1, p112
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.201300139