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- Title
Identification of polychlorinated dibenzofurans in environmental samples.
- Authors
Rappe, Christoffer; Buser, Hans Rudolf; Stalling, David L.; Smith, Lawrence M.; Dougherty, Ralph C.
- Abstract
The polychlorinated dibenzofurans (PCDFs) are tricyclic aromatic compounds, which in chemical and toxicological respects are very similar to polychlorinated dioxins (PCDDs). The 2,3,7,8-tetra-, 1,2,3,7,8- and 2,3,4,7,8-penta-CDFs are extremely hazardous compounds, they can be compared with the extremely toxic 2,3,7,8-tetra-CDD (ref. 1). PCDFs have been identified in PCBs at levels of 1-10 p.p.m., the major peaks being 2,3,7,8-tetra- and 2,3,4,7,8-penta-CDF (refs 2-4). A large number of PCDFs and PCDDs occur as contaminants in chlorophenols5-7, and they have also been recognized and identified in fly ash and other incineration products at the p.p.b.-p.p.m. level18-11. In 1968,1,200 people in Japan were poisoned (Yusho disease) by a cooking oil contaminated by PCB12 and more than 50 PCDF isomers13. Liver samples from exposed patients were found to contain a highly reduced number of PCDFs, apparently many isomers were excreted or metabolized14. We report here the identification of a series of PCDF isomers in environmental samples.
- Publication
Nature, 1981, Vol 292, Issue 5823, p524
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/292524a0